The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor()

Sleeping Beauty (SB()) transposon and transposase constitute a DNA plasmid system used for therapeutic human cell genetic engineering. Here we report a comparison of SB100X, a newly developed hyperactive SB transposase, to a previous generation SB11 transposase to achieve stable expression of a CD19...

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Autori principali: Jin, Zeming, Maiti, Sourindra, Huls, Helen, Singh, Harjeet, Olivares, Simon, Mátés, Lajos, Izsvák, Zsuzsanna, Ivics, Zoltán, Lee, Dean A., Champlin, Richard E., Cooper, Laurence J.N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083583/
https://ncbi.nlm.nih.gov/pubmed/21451576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.40
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