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Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy
Wnt signaling is important for cancer pathogenesis and is often upregulated in hepatocellular carcinoma (HCC). Heparan sulfate proteoglycans (HSPGs) function as co-receptors or modulators of Wnt activation. Glypican-3 (GPC3) is a HSPG that is highly expressed in HCC, where it can attract Wnt protein...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4083010/ https://ncbi.nlm.nih.gov/pubmed/24492943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26996 |
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