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Human Monoclonal Antibody Targeting the Heparan Sulfate Chains of Glypican-3 Inhibits HGF-Mediated Migration and Motility of Hepatocellular Carcinoma Cells

Heparan sulfate proteoglycans (HSPGs) participate in many processes related to tumor development, including tumorigenesis and metastasis. HSPGs contain one or more heparan sulfate (HS) chains that are covalently linked to a core protein. Glypican-3 (GPC3) is a cell surface-associated HSPG that is hi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gao, Wei, Kim, Heungnam, Ho, Mitchell
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557904/
https://ncbi.nlm.nih.gov/pubmed/26332121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137664
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