Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse

BACKGROUND: Thrombin undergoes convective and diffusive transport, making it difficult to visualize during thrombosis. We developed the first sensor capable of revealing inner clot thrombin dynamics. METHODS AND RESULTS: An N-terminal-azido thrombin-sensitive fluorescent peptide (ThS-P) with a throm...

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Bibliografische gegevens
Hoofdauteurs: WELSH, J. D., COLACE, T. V., MUTHARD, R. W., STALKER, T. J., BRASS, L. F., DIAMOND, S. L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082909/
https://ncbi.nlm.nih.gov/pubmed/22978514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2012.04928.x
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