Influence of aeration–homogenization system in stirred tank bioreactors, dissolved oxygen concentration and pH control mode on BHK-21 cell growth and metabolism

This work focused on determining the effect of dissolved oxygen concentration (DO) on growth and metabolism of BHK-21 cell line (host cell for recombinant proteins manufacturing and viral vaccines) cultured in two stirred tank bioreactors with different aeration-homogenization systems, as well as pH...

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Detalhes bibliográficos
Main Authors: Núñez, Eutimio Gustavo Fernández, Leme, Jaci, de Almeida Parizotto, Letícia, Chagas, Wagner Antonio, de Rezende, Alexandre Gonçalves, da Costa, Bruno Labate Vale, Monteiro, Daniela Cristina Ventini, Boldorini, Vera Lucia Lopes, Jorge, Soraia Attie Calil, Astray, Renato Mancini, Pereira, Carlos Augusto, Caricati, Celso Pereira, Tonso, Aldo
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082785/
https://ncbi.nlm.nih.gov/pubmed/23846480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-013-9612-0
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