MODEL COMPARISON TO DESCRIBE BHK-21 CELL GROWTH AND METABOLISM IN STIRRED TANK BIOREACTORS OPERATED IN BATCH MODE

Abstract Baby Hamster Kidney cells (BHK-21) are commonly used in research and the biopharmaceutical industry. This work aimed to model the kinetic performance in batch operation mode of BHK-21 cells cultured in two stirred tank configurations using different dissolved oxygen concentrations and pH co...

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Detalhes bibliográficos
Main Authors: Roger Sartori, Jaci Leme, Celso Pereira Caricati, Aldo Tonso, Eutimio Gustavo Fernández Núñez
Formato: Artigo
Idioma:Inglês
Publicado em: Brazilian Society of Chemical Engineering
Colecção:Brazilian Journal of Chemical Engineering
Assuntos:
batch operation
bioprocess engineering
mammalian cell culture
mathematical modelling
stirred tank bioreactor
Acesso em linha:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322018000200441&lng=en&tlng=en
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