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Transcriptional dysregulation in Huntington’s disease: a failure of adaptive transcriptional homeostasis
Huntington’s disease (HD) is a signature polyglutamine disorder. An enduring theory of HD pathogenesis has involved dysregulation of transcription. Indeed, transcriptional regulatory proteins can be modulated to overcome cardinal features of HD-modeled mice, and efforts to move these into human stud...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4082751/ https://ncbi.nlm.nih.gov/pubmed/24662036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2014.03.016 |
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