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Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury

Heme oxygenase-1 (HO-1) confers protection against a variety of oxidant-induced cell and tissue injury. In this study, we examined whether exogenous administration of HO-1 by gene transfer could also confer protection. We first demonstrated the feasibility of overexpressing HO-1 in the lung by gene...

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Autori principali: Otterbein, Leo E., Kolls, Jay K., Mantell, Lin L., Cook, Julia L., Alam, Jawed, Choi, Augustine M.K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC408257/
https://ncbi.nlm.nih.gov/pubmed/10194478
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