The Rodin-Ohno hypothesis that two enzyme superfamilies descended from one ancestral gene: an unlikely scenario for the origins of translation that will not be dismissed

BACKGROUND: Because amino acid activation is rate-limiting for uncatalyzed protein synthesis, it is a key puzzle in understanding the origin of the genetic code. Two unrelated classes (I and II) of contemporary aminoacyl-tRNA synthetases (aaRS) now translate the code. Observing that codons for the m...

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Detalhes bibliográficos
Main Authors: Carter, Charles W, Li, Li, Weinreb, Violetta, Collier, Martha, Gonzalez-Rivera, Katiria, Jimenez-Rodriguez, Mariel, Erdogan, Ozgün, Kuhlman, Brian, Ambroggio, Xavier, Williams, Tishan, Chandrasekharan, S Niranj
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082485/
https://ncbi.nlm.nih.gov/pubmed/24927791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6150-9-11
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