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A Dual-Targeting, p53-Independent, Apoptosis-Inducing Platinum(II) Anticancer Complex, [Pt(BDI(QQ))]Cl

The therapeutic index and cellular mechanism of action of [Pt(BDI(QQ))]Cl, a monocationic, square-planar platinum(II) complex, are reported. [Pt(BDI(QQ))]Cl was used to treat several cell lines, including wild type and cisplatin-resistant ovarian carcinoma cells (A2780 and A2780CP70) and non-prolife...

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Bibliografiske detaljer
Main Authors: Suntharalingam, Kogularamanan, Wilson, Justin J., Lin, Wei, Lippard, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082332/
https://ncbi.nlm.nih.gov/pubmed/24514456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3mt00364g
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