Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

Estrogens play a major role in the modulation of energy balance through central and peripheral actions. Here, we demonstrate that central action of estradiol (E2) inhibits AMP-activated protein kinase (AMPK) through estrogen receptor alpha (ERα) selectively in the ventromedial nucleus of the hypotha...

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Main Authors: Martínez de Morentin, Pablo B., González-García, Ismael, Martins, Luís, Lage, Ricardo, Fernández-Mallo, Diana, Martínez-Sánchez, Noelia, Ruíz-Pino, Francisco, Liu, Ji, Morgan, Donald A., Pinilla, Leonor, Gallego, Rosalía, Saha, Asish K., Kalsbeek, Andries, Fliers, Eric, Bisschop, Peter H., Diéguez, Carlos, Nogueiras, Rubén, Rahmouni, Kamal, Tena-Sempere, Manuel, López, Miguel
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082097/
https://ncbi.nlm.nih.gov/pubmed/24856932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.03.031
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