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Endothelial Nitric Oxide Synthase and Superoxide Mediate Hemodynamic Initiation of Intracranial Aneurysms

BACKGROUND: Hemodynamic insults at arterial bifurcations are believed to play a critical role in initiating intracranial aneurysms. Recent studies in a rabbit model indicate that aneurysmal damage initiates under specific wall shear stress conditions when smooth muscle cells (SMCs) become pro-inflam...

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Detalhes bibliográficos
Main Authors: Liaw, Nicholas, Dolan Fox, Jennifer M., Siddiqui, Adnan H., Meng, Hui, Kolega, John
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081806/
https://ncbi.nlm.nih.gov/pubmed/24992254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101721
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