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QSAR-Based Models for Designing Quinazoline/Imidazothiazoles/Pyrazolopyrimidines Based Inhibitors against Wild and Mutant EGFR

Overexpression of EGFR is responsible for causing a number of cancers, including lung cancer as it activates various downstream signaling pathways. Thus, it is important to control EGFR function in order to treat the cancer patients. It is well established that inhibiting ATP binding within the EGFR...

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מידע ביבליוגרפי
Main Authors: Chauhan, Jagat Singh, Dhanda, Sandeep Kumar, Singla, Deepak, Agarwal, Subhash M., Raghava, Gajendra P. S.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081576/
https://ncbi.nlm.nih.gov/pubmed/24992720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101079
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