Benzylideneacetophenone derivatives attenuate IFN-γ-induced IP-10/CXCL10 production in orbital fibroblasts of patients with thyroid-associated ophthalmopathy through STAT-1 inhibition

The aim of the present study was to identify a new candidate anti-inflammatory compound for use in the active stage of thyroid-associated ophthalmopathy (TAO). Benzylideneacetophenone compound JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] was synthesized based on a structural modifica...

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Detalhes bibliográficos
Main Authors: Lee, Sung-Hee, Lim, Seul Ye, Choi, Ji Ha, Jung, Jae-Chul, Oh, Seikwan, Kook, Koung Hoon, Choi, Youn-Hee
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081550/
https://ncbi.nlm.nih.gov/pubmed/24924312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2014.26
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