Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease

The ε4 allele of apolipoprotein E (apo E) is associated with an increased risk for developing Alzheimer's disease (AD). This may be due to interactions between apo E and the amyloid-β protein (Aβ). To assess the effects of human apo E isoforms on Aβ deposition in vivo, we bred apo E3 and apo E4...

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Détails bibliographiques
Auteurs principaux: Holtzman, David M., Bales, Kelly R., Wu, Shan, Bhat, Priyanka, Parsadanian, Maia, Fagan, Anne M., Chang, Louis K., Sun, Yuling, Paul, Steven M.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1999
Sujets:
Rapid Publication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC408154/
https://ncbi.nlm.nih.gov/pubmed/10079115
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