Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression

Motivation: A typical genome-wide association study searches for associations between single nucleotide polymorphisms (SNPs) and a univariate phenotype. However, there is a growing interest to investigate associations between genomics data and multivariate phenotypes, for example, in gene expression...

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Main Authors: Marttinen, Pekka, Pirinen, Matti, Sarin, Antti-Pekka, Gillberg, Jussi, Kettunen, Johannes, Surakka, Ida, Kangas, Antti J., Soininen, Pasi, O’Reilly, Paul, Kaakinen, Marika, Kähönen, Mika, Lehtimäki, Terho, Ala-Korpela, Mika, Raitakari, Olli T., Salomaa, Veikko, Järvelin, Marjo-Riitta, Ripatti, Samuli, Kaski, Samuel
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Original Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080737/
https://ncbi.nlm.nih.gov/pubmed/24665129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu140
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