Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model

Despite evidence that deregulated Notch signalling is a master regulator of multiple myeloma (MM) pathogenesis, its contribution to myeloma bone disease remains to be resolved. Notch promotes survival of human MM cells and triggers human osteoclast activity in vitro. Here, we show that inhibition of...

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Autori principali: Schwarzer, R, Nickel, N, Godau, J, Willie, B M, Duda, G N, Cirovic, B, Leutz, A, Manz, R, Bogen, B, Dörken, B, Jundt, F
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080208/
https://ncbi.nlm.nih.gov/pubmed/24927406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2014.37
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