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Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model

Despite evidence that deregulated Notch signalling is a master regulator of multiple myeloma (MM) pathogenesis, its contribution to myeloma bone disease remains to be resolved. Notch promotes survival of human MM cells and triggers human osteoclast activity in vitro. Here, we show that inhibition of...

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書誌詳細
主要な著者: Schwarzer, R, Nickel, N, Godau, J, Willie, B M, Duda, G N, Cirovic, B, Leutz, A, Manz, R, Bogen, B, Dörken, B, Jundt, F
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080208/
https://ncbi.nlm.nih.gov/pubmed/24927406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2014.37
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