Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model

Despite evidence that deregulated Notch signalling is a master regulator of multiple myeloma (MM) pathogenesis, its contribution to myeloma bone disease remains to be resolved. Notch promotes survival of human MM cells and triggers human osteoclast activity in vitro. Here, we show that inhibition of...

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Bibliographische Detailangaben
Hauptverfasser: Schwarzer, R, Nickel, N, Godau, J, Willie, B M, Duda, G N, Cirovic, B, Leutz, A, Manz, R, Bogen, B, Dörken, B, Jundt, F
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080208/
https://ncbi.nlm.nih.gov/pubmed/24927406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2014.37
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