Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis

Individuals with familial adenomatous polyposis (FAP) harbor a germline mutation in adenomatous polyposis coli (APC). The major clinical manifestation is development of multiple colonic tumors at a young age due to stochastic loss of the remaining APC allele. Extracolonic features, including periamp...

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Bibliographic Details
Main Authors: Powell, Anne E., Vlacich, Gregory, Zhao, Zhen-Yang, McKinley, Eliot T., Washington, M. Kay, Manning, H. Charles, Coffey, Robert J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080164/
https://ncbi.nlm.nih.gov/pubmed/24833705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00358.2013
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