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Role of 2′,3′-cyclic nucleotide 3′-phosphodiesterase in the renal 2′,3′-cAMP-adenosine pathway

Energy depletion increases the renal production of 2′,3′-cAMP (a positional isomer of 3′,5′-cAMP that opens mitochondrial permeability transition pores) and 2′,3′-cAMP is converted to 2′-AMP and 3′-AMP, which in turn are metabolized to adenosine. Because the enzymes involved in this “2′,3′-cAMP-aden...

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Bibliografske podrobnosti
Main Authors: Jackson, Edwin K., Gillespie, Delbert G., Mi, Zaichuan, Cheng, Dongmei, Bansal, Rashmi, Janesko-Feldman, Keri, Kochanek, Patrick M.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080157/
https://ncbi.nlm.nih.gov/pubmed/24808540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00134.2014
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