Dysferlin regulates cell membrane repair by facilitating injury-triggered acid sphingomyelinase secretion

Dysferlin deficiency compromises the repair of injured muscle, but the underlying cellular mechanism remains elusive. To study this phenomenon, we have developed mouse and human myoblast models for dysferlinopathy. These dysferlinopathic myoblasts undergo normal differentiation but have a deficit in...

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Autori principali: Defour, A, Van der Meulen, J H, Bhat, R, Bigot, A, Bashir, R, Nagaraju, K, Jaiswal, J K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079937/
https://ncbi.nlm.nih.gov/pubmed/24967968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.272
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