Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor CD4+ T cell responses through the PD-1/PD-L1 axis

In recent years, immune-based therapies have become an increasingly attractive treatment option for patients with cancer. Cancer immunotherapy is often used in combination with conventional chemotherapy for synergistic effects. The alkylating agent cyclophosphamide (CTX) has been included in various...

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Bibliografiska uppgifter
Huvudupphovsmän: Ding, Zhi-Chun, Lu, Xiaoyun, Yu, Miao, Lemos, Henrique, Huang, Lei, Chandler, Phillip, Liu, Kebin, Walters, Matthew, Krasinski, Antoni, Mack, Matthias, Blazar, Bruce R., Mellor, Andrew L., Munn, David H., Zhou, Gang
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079842/
https://ncbi.nlm.nih.gov/pubmed/24780756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3596
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