Liver Damage, Inflammation and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition

Obesity can result in insulin resistance, hepatosteatosis and non-alcoholic steatohepatitis (NASH) and increases liver cancer risk. Obesity-induced insulin resistance depends, in part, on chronic activation of mammalian target of rapamycin complex 1 (mTORC1), which also occurs in human and mouse hep...

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Bibliographische Detailangaben
Hauptverfasser: Umemura, Atsushi, Park, Eek Joong, Taniguchi, Koji, Lee, Jun Hee, Shalapour, Shabnam, Valasek, Mark A., Aghajan, Mariam, Nakagawa, Hayato, Seki, Ekihiro, Hall, Michael N., Karin, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079758/
https://ncbi.nlm.nih.gov/pubmed/24910242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.05.001
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