Old drug new use - Amoxapine and its metabolites as potent bacterial β-glucuronidase inhibitors for alleviating cancer drug toxicity

PURPOSE: Irinotecan (CPT-11) induced diarrhea occurs frequently in cancer patients and limits its usage. Bacteria β-glucuronidase (GUS) enzymes in intestines convert the non-toxic metabolite of CPT-11, SN-38G, to toxic SN-38, and finally lead to damage of intestinal epithelial cells and diarrhea. We...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kong, Ren, Liu, Timothy, Zhu, Xiaoping, Ahmad, Syed, Williams, Alfred L., Phan, Alexandria T, Zhao, Hong, Scott, John E., Yeh, Li-An, Wong, Stephen TC
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079752/
https://ncbi.nlm.nih.gov/pubmed/24780296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0395
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