Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes.

Articular cartilage chondrocytes have the unique ability to elaborate large amounts of extracellular pyrophosphate (PPi), and transforming growth factor beta (TGF beta) appears singular among cartilage regulatory factors in stimulating PPi production. TGF beta caused a time and dose-dependent increa...

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Detalhes bibliográficos
Main Authors: Lotz, M, Rosen, F, McCabe, G, Quach, J, Blanco, F, Dudler, J, Solan, J, Goding, J, Seegmiller, J E, Terkeltaub, R
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC40797/
https://ncbi.nlm.nih.gov/pubmed/7479785
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