Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation

To identify small molecules that selectively control hematopoietic stem cell (HSC) differentiation, we performed an unbiased screen using primary human CD34+ cells. We identified a plant-derived natural product, euphohelioscopin A, capable of selectively differentiating CD34+ cells down the granuloc...

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Autors principals: de Lichtervelde, Lorenzo, Antal, Corina E., Boitano, Anthony E., Wang, Ying, Krastel, Philipp, Petersen, Frank, Newton, Alexandra C., Cooke, Michael P., Schultz, Peter G.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079670/
https://ncbi.nlm.nih.gov/pubmed/22921066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.06.010
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