Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia

BACKGROUND: Sickle cell anemia is an inherited disorder of hemoglobin that leads to a variety of acute and chronic complications. Abnormal cellular adhesion, mediated in part by selectins, has been implicated in the pathophysiology of the vaso-occlusion seen in sickle cell anemia, and selectin inhib...

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Autors principals: Wun, Ted, Styles, Lori, DeCastro, Laura, Telen, Marilyn J., Kuypers, Frans, Cheung, Anthony, Kramer, William, Flanner, Henry, Rhee, Seungshin, Magnani, John L., Thackray, Helen
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079300/
https://ncbi.nlm.nih.gov/pubmed/24988449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101301
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