Weak Negative and Positive Selection and the Drift Load at Splice Sites

Splice sites (SSs) are short sequences that are crucial for proper mRNA splicing in eukaryotic cells, and therefore can be expected to be shaped by strong selection. Nevertheless, in mammals and in other intron-rich organisms, many of the SSs often involve nonconsensus (Nc), rather than consensus (C...

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Main Authors: Denisov, Stepan V., Bazykin, Georgii A., Sutormin, Roman, Favorov, Alexander V., Mironov, Andrey A., Gelfand, Mikhail S., Kondrashov, Alexey S.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079205/
https://ncbi.nlm.nih.gov/pubmed/24966225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evu100
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