Isolation and Molecular Characterization of Circulating Melanoma Cells

Melanoma is an invasive malignancy with a high frequency of blood-borne metastases, but circulating tumor cells (CTCs) have not been readily isolated. We adapted microfluidic CTC capture to a tamoxifen-driven B-RAF/PTEN mouse melanoma model. CTCs were detected in all tumor-bearing mice, rapidly decl...

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Main Authors: Luo, Xi, Mitra, Devarati, Sullivan, Ryan J., Wittner, Ben S., Kimura, Anya M., Pan, Shiwei, Hoang, Mai P., Brannigan, Brian W., Lawrence, Donald P., Flaherty, Keith T., Sequist, Lecia V., McMahon, Martin, Bosenberg, Marcus W., Stott, Shannon L., Ting, David T., Ramaswamy, Sridhar, Toner, Mehmet, Fisher, David E., Maheswaran, Shyamala, Haber, Daniel A.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079008/
https://ncbi.nlm.nih.gov/pubmed/24746818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.03.039
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