Lis1 Reduction Causes Tangential Migratory Errors in Mouse Spinal Cord

Mutations in human LIS1 cause abnormal neuronal migration and a smooth brain phenotype known as lissencephaly. Lis1(+/−) (Pafah1b1) mice show defective lamination in the cerebral cortex and hippocampal formation, whereas homozygous mutations result in embryonic lethality. Given that Lis1 is highly e...

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Bibliographic Details
Main Authors: Moore, Katherine D., Chen, Renee, Cilluffo, Marianne, Golden, Jeffrey A., Phelps, Patricia E.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079006/
https://ncbi.nlm.nih.gov/pubmed/21935943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.22768
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