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An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function

Defining the processes of autoimmune attack of tissues is important for inhibiting continued tissue destruction. In type 1 diabetes, it is not known how cytotoxic effector T cell responses evolve over time in the pancreatic islets targeted for destruction. We used two-photon microscopy of live, inta...

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Autors principals: Friedman, Rachel S., Lindsay, Robin S., Lilly, Jason K., Nguyen, Vinh, Sorensen, Caitlin M., Jacobelli, Jordan, Krummel, Matthew F.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078867/
https://ncbi.nlm.nih.gov/pubmed/24927530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322193111
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