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An iron-regulated and glycosylation-dependent proteasomal degradation pathway for the plasma membrane metal transporter ZIP14

Protein degradation is instrumental in regulating cellular function. Plasma membrane proteins targeted for degradation are internalized and sorted to multivesicular bodies, which fuse with lysosomes, where they are degraded. ZIP14 is a newly identified iron transporter with multitransmembrane domain...

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Main Authors: Zhao, Ningning, Zhang, An-Sheng, Worthen, Christal, Knutson, Mitchell D., Enns, Caroline A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078863/
https://ncbi.nlm.nih.gov/pubmed/24927598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405355111
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