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An iron-regulated and glycosylation-dependent proteasomal degradation pathway for the plasma membrane metal transporter ZIP14

Protein degradation is instrumental in regulating cellular function. Plasma membrane proteins targeted for degradation are internalized and sorted to multivesicular bodies, which fuse with lysosomes, where they are degraded. ZIP14 is a newly identified iron transporter with multitransmembrane domain...

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Autori principali: Zhao, Ningning, Zhang, An-Sheng, Worthen, Christal, Knutson, Mitchell D., Enns, Caroline A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078863/
https://ncbi.nlm.nih.gov/pubmed/24927598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405355111
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