Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses

CD8 T-cell responses to liver-expressed antigens range from deletional tolerance to full effector differentiation resulting in overt hepatotoxicity. The reasons for these heterogeneous outcomes are not well understood. To identify factors that govern the fate of CD8 T cells activated by hepatocyte-e...

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Bibliografiske detaljer
Main Authors: Tay, Szun Szun, Wong, Yik Chun, McDonald, David M., Wood, Nicole A. W., Roediger, Ben, Sierro, Frederic, Mcguffog, Claire, Alexander, Ian E., Bishop, G. Alex, Gamble, Jennifer R., Weninger, Wolfgang, McCaughan, Geoffrey W., Bertolino, Patrick, Bowen, David G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078818/
https://ncbi.nlm.nih.gov/pubmed/24927525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406674111
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