Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses

CD8 T-cell responses to liver-expressed antigens range from deletional tolerance to full effector differentiation resulting in overt hepatotoxicity. The reasons for these heterogeneous outcomes are not well understood. To identify factors that govern the fate of CD8 T cells activated by hepatocyte-e...

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Bibliographische Detailangaben
Hauptverfasser: Tay, Szun Szun, Wong, Yik Chun, McDonald, David M., Wood, Nicole A. W., Roediger, Ben, Sierro, Frederic, Mcguffog, Claire, Alexander, Ian E., Bishop, G. Alex, Gamble, Jennifer R., Weninger, Wolfgang, McCaughan, Geoffrey W., Bertolino, Patrick, Bowen, David G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078818/
https://ncbi.nlm.nih.gov/pubmed/24927525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406674111
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