Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs

Hemophilia A, one of the most common genetic bleeding disorders, is caused by various mutations in the blood coagulation factor VIII (F8) gene. Among the genotypes that result in hemophilia A, two different types of chromosomal inversions that involve a portion of the F8 gene are most frequent, acco...

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Bibliografiska uppgifter
Huvudupphovsmän: Park, Chul-Yong, Kim, Jungeun, Kweon, Jiyeon, Son, Jeong Sang, Lee, Jae Souk, Yoo, Jeong-Eun, Cho, Sung-Rae, Kim, Jong-Hoon, Kim, Jin-Soo, Kim, Dong-Wook
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078797/
https://ncbi.nlm.nih.gov/pubmed/24927536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323941111
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