CD4(+) T Cells Modified by the Endoribonuclease MazF Are Safe and Can Persist in SHIV-infected Rhesus Macaques

MazF, an endoribonuclease encoded by Escherichia coli, specifically cleaves the ACA (adenine–cytosine–adenine) sequence of single-stranded RNAs. Conditional expression of MazF under the control of the HIV-1 LTR promoter rendered CD4(+) T cells resistant to HIV-1 replication without affecting cell gr...

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Detalhes bibliográficos
Main Authors: Saito, Naoki, Chono, Hideto, Shibata, Hiroaki, Ageyama, Naohide, Yasutomi, Yasuhiro, Mineno, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078760/
https://ncbi.nlm.nih.gov/pubmed/24914931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.20
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