In Vivo Safety and Persistence of Endoribonuclease Gene-Transduced CD4+ T Cells in Cynomolgus Macaques for HIV-1 Gene Therapy Model

BACKGROUND: MazF is an endoribonuclease encoded by Escherichia coli that specifically cleaves the ACA sequence of mRNA. In our previous report, conditional expression of MazF in the HIV-1 LTR rendered CD4+ T lymphocytes resistant to HIV-1 replication. In this study, we examined the in vivo safety an...

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Hauptverfasser: Chono, Hideto, Saito, Naoki, Tsuda, Hiroshi, Shibata, Hiroaki, Ageyama, Naohide, Terao, Keiji, Yasutomi, Yasuhiro, Mineno, Junichi, Kato, Ikunoshin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157387/
https://ncbi.nlm.nih.gov/pubmed/21858176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023585
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