A novel leukocyte adhesion deficiency caused by expressed but nonfunctional β2 integrins Mac-1 and LFA-1

In the leukocyte adhesion deficiency (LAD)-1 syndrome, there is diminished expression of β2(CD18) integrins. This is caused by lesions in the β2-subunit gene and gives rise to recurrent bacterial infections, impaired pus formation, and poor wound healing. We describe a patient with clinical features...

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Main Authors: Hogg, Nancy, Stewart, Mairi P., Scarth, Sarah L., Newton, Rebecca, Shaw, Jacqueline M., Law, S.K. Alex, Klein, Nigel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC407855/
https://ncbi.nlm.nih.gov/pubmed/9884339
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