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Crystal structure of the [Mg(2+)-(chromomycin A(3))(2)]–d(TTGGCCAA)(2) complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion
The anticancer antibiotic chromomycin A(3) (Chro) is a DNA minor groove binding drug belonging to the aureolic family. Chro likely exerts its activity by interfering with replication and transcription. Chro forms a dimer, mediated by a divalent metal ion, which binds to G/C-rich DNA. Herein we repor...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC407830/ https://ncbi.nlm.nih.gov/pubmed/15107489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh549 |
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