The Rational Design of Specific Peptide Inhibitor against p38α MAPK at Allosteric-Site: A Therapeutic Modality for HNSCC

p38α is a significant target for drug designing against cancer. The overproduction of p38α MAPK promotes tumorigenesis in head and neck squamous cell carcinoma (HNSCC). The ATP binding and an allosteric site referred as DFG are the key sites of the p38α mitogen activated protein kinase (MAPK) exploi...

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Détails bibliographiques
Auteurs principaux: Gill, Kamaldeep, Nigam, Lokesh, Singh, Ratnakar, Kumar, Suresh, Subbarao, Naidu, Chauhan, Shyam Singh, Dey, Sharmistha
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077802/
https://ncbi.nlm.nih.gov/pubmed/24983631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101525
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