Genotyping Cancer-Associated Genes in Chordoma Identifies Mutations in Oncogenes and Areas of Chromosomal Loss Involving CDKN2A, PTEN, and SMARCB1

The molecular mechanisms underlying chordoma pathogenesis are unknown. We therefore sought to identify novel mutations to better understand chordoma biology and to potentially identify therapeutic targets. Given the relatively high costs of whole genome sequencing, we performed a focused genetic ana...

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Auteurs principaux: Choy, Edwin, MacConaill, Laura E., Cote, Gregory M., Le, Long P., Shen, Jacson K., Nielsen, Gunnlaugur P., Iafrate, Anthony J., Garraway, Levi A., Hornicek, Francis J., Duan, Zhenfeng
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077728/
https://ncbi.nlm.nih.gov/pubmed/24983247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101283
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