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A novel bidirectional positive-feedback loop between Wnt–β-catenin and EGFR–ERK plays a role in context-specific modulation of epithelial tissue regeneration

By operating as both a subunit of the cadherin complex and a key component of Wnt signalling, β-catenin acts as the lynchpin between cell–cell contact and transcriptional regulation of proliferation, coordinating epithelial tissue homeostasis and regeneration. The integration of multiple growth-regu...

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Bibliographic Details
Main Authors: Georgopoulos, Nikolaos T., Kirkwood, Lisa A., Southgate, Jennifer
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077591/
https://ncbi.nlm.nih.gov/pubmed/24816560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.150888
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