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Local transdermal delivery of phenylephrine to the anal sphincter muscle using microneedles
We propose pretreatment using microneedles to increase perianal skin permeability for locally targeted delivery of phenylephrine (PE), a drug that increases resting anal sphincter pressure to treat fecal incontinence. Microneedle patches were fabricated by micromolding poly-lactic-acid. Pre-treatmen...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4077336/ https://ncbi.nlm.nih.gov/pubmed/21586307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2011.05.004 |
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