Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide

PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to a region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death by a process called DNA interference. PNT2258 is PNT100 that is encapsulated...

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Autori principali: Rodrigueza, Wendi V., Woolliscroft, Michael J., Ebrahim, Abdul-Shukkur, Forgey, Robert, McGovren, Patrick J., Endert, Gerold, Wagner, Andreas, Holewa, Danielle, Aboukameel, Amro, Gill, Richard D., Bisgaier, Charles L., Messmann, Richard A., Whitehead, Christopher E., Izbicka, Elzbieta, Streeper, Robert, Wick, Michael C., Stiegler, Gabriela, Stein, C. A., Monsma, David, Webb, Craig, Sooch, Mina P., Panzner, Steffen, Mohammad, Ramzi, Goodwin, Neal C., Al-Katib, Ayad
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077254/
https://ncbi.nlm.nih.gov/pubmed/24832107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2476-y
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