Galectin-9 Is Rapidly Released During Acute HIV-1 Infection and Remains Sustained at High Levels Despite Viral Suppression Even in Elite Controllers

Galectin-9 (Gal-9) is a β-galactosidase-binding lectin that promotes apoptosis, tissue inflammation, and T cell immune exhaustion, and alters HIV infection in part through engagement with the T cell immunoglobulin mucin domain-3 (Tim-3) receptor and protein disulfide isomerases (PDI). Gal-9 was init...

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Detalhes bibliográficos
Main Authors: Tandon, Ravi, Chew, Glen M., Byron, Mary M., Borrow, Persephone, Niki, Toshiro, Hirashima, Mitsuomi, Barbour, Jason D., Norris, Philip J., Lanteri, Marion C., Martin, Jeffrey N., Deeks, Steven G., Ndhlovu, Lishomwa C.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077009/
https://ncbi.nlm.nih.gov/pubmed/24786365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2014.0004
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