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Selective Ablation of Ppp1cc Gene in Testicular Germ Cells Causes Oligo-Teratozoospermia and Infertility in Mice

The four isoforms of serine/threonine phosphoprotein phosphatase 1 (PP1), derived from three genes, are among the most conserved proteins known. The Ppp1cc gene encodes two alternatively spliced variants, PP1 gamma1 (PPP1CC1) and PP1 gamma2 (PPP1CC2). Global deletion of the Ppp1cc gene, which causes...

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Detalles Bibliográficos
Main Authors: Sinha, Nilam, Puri, Pawan, Nairn, Angus C., Vijayaraghavan, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado: Society for the Study of Reproduction, Inc. 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076382/
https://ncbi.nlm.nih.gov/pubmed/24089200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.113.110239
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