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A Chemical Strategy for the Cell-Based Detection of HDAC Activity
[Image: see text] A strategy for activity-based enzyme detection using a novel enamide-based chemical strategy is described. Enzymatic cleavage of an amide bond results in the formation of an aldehyde. The interaction of this aldehyde with proteins increases retention in cells that express the enzym...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2014
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4076023/ https://ncbi.nlm.nih.gov/pubmed/25056147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500248r |
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