The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation

Activation by the Y-encoded testis determining factor SRY and maintenance of expression of the Sox9 gene encoding the central transcription factor of Sertoli cell differentiation are key events in the mammalian sexual differentiation program. In the mouse XY gonad, SOX9 upregulates Fgf9, which initi...

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Détails bibliographiques
Auteurs principaux: Moniot, Brigitte, Declosmenil, Faustine, Barrionuevo, Francisco, Scherer, Gerd, Aritake, Kosuke, Malki, Safia, Marzi, Laetitia, Cohen-Solal, Anne, Georg, Ina, Klattig, Jürgen, Englert, Christoph, Kim, Yuna, Capel, Blanche, Eguchi, Naomi, Urade, Yoshihiro, Boizet-Bonhoure, Brigitte, Poulat, Francis
Format: Artigo
Langue:Inglês
Publié: Oxford University Press for The Company of Biologists Limited 2009
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075598/
https://ncbi.nlm.nih.gov/pubmed/19429785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.032631
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