Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP

Uveal melanoma (UM) is the most common cancer in adult eyes. Approximately eighty percent of UMs harbor somatic activating mutations in GNAQ or GNA11 (encodes Gq or G11 respectively). Herein, we show in both cell culture and human tumors that cancer-associated Gq/11 mutants activate YAP, a major eff...

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Detalhes bibliográficos
Main Authors: Yu, Fa-Xing, Luo, Jing, Mo, Jung-Soon, Liu, Guangbo, Kim, Young Chul, Meng, Zhipeng, Zhao, Ling, Peyman, Gholam, Ouyang, Hong, Jiang, Wei, Zhao, Jiagang, Chen, Xu, Zhang, Liangfang, Wang, Cun-Yu, Bastian, Boris C., Zhang, Kang, Guan, Kun-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075337/
https://ncbi.nlm.nih.gov/pubmed/24882516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.04.017
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