PKCλ Haploinsufficiency Prevents Diabetes by a Mechanism Involving Alterations in Hepatic Enzymes

Tissue-specific knockout (KO) of atypical protein kinase C (aPKC), PKC-λ, yields contrasting phenotypes, depending on the tissue. Thus, whereas muscle KO of PKC-λ impairs glucose transport and causes glucose intolerance, insulin resistance, and liver-dependent lipid abnormalities, liver KO and adipo...

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Detalhes bibliográficos
Main Authors: Sajan, Mini P., Ivey, Robert A., Lee, Mackenzie, Mastorides, Stephen, Jurczak, Michael J., Samuels, Varman T., Shulman, Gerald I., Braun, Ursula, Leitges, Michael, Farese, Robert V.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075159/
https://ncbi.nlm.nih.gov/pubmed/24877563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1025
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